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Boğaziçi Üniversitesi Tezleri: Recent submissions

Now showing items 401-420 of 7882

Preservice mathematics teachers’ promotion of self-regulated (PSRL) in time : a mixed-method study

Cihangir, Meryem. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2022., 2022)

These two-phased mixed method quasi-experimental study was conducted to investigate preservice mathematics teachers’ promotion of self-regulated learning (PSRL) with respect to time through participation in a self-regulated ...
Investigating mathematics teacher educators’ specialised knowledge for teaching geometric transformations

Balcı, Hüsniye Aybüke. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2022., 2022)

In this study, three mathematics teacher educators’(MTEs) specialised knowl edge for geometric transformations was explored. In this regard, MTEs’ mathematical knowledge about geometric transformations including the ...
Exploring preservice science teachers’ progression on designing simulation-enhanced inquiry-based lesson for asynchronous learning environments

Özergun, Ilgım. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2022., 2022)

The aim of this study was to explore preservice science teachers’ progression on designing simulation-enhanced inquiry-based lesson for asynchronous learning environments. A module entitled Simulation-enhanced Inquiry-based ...
The inclusion of the nature of science in Turkish science curriculum

Kurt, Gözde. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2022., 2022)

The Reconceptualized Family Resemblance Approach to Nature of Science (RFN) is a comprehensive approach that consists of the cognitive-epistemic and social institutional systems of science (Erduran & Dagher, 2014a; Kaya ...
Investigating preservice teachers' content knowledge on multiplication and division

Karyağdı, Banu. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2022., 2022)

The aim of the current study was to investigate preservice teachers’ content knowledge on multiplication and division. The study was conducted in five universities in Turkey, during the Spring semester of 2021-2022 ...
Characterization of GPR139 and investigating its possible role in brain development

Aslan, Tolga. (Thesis (Ph.D.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2022., 2022)

G protein coupled receptors are a large family of cell surface receptors and are involved in a plethora of physiological functions from vision to various neuronal func tions. They have been a major target in the pharmaceutical ...
Investigation of the effects of SUMO modification on two critical proteins : a pathogenic NEK1 mutant that drives ALS pathogenesis and the CRISPR-associated CAS9 protein

Ergünay, Tunahan. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2022., 2022)

Small Ubiquitin-like modifier (SUMO) is an essential eukaryotic post-translational modification. SUMO isoforms attach to specific lysine residues on target substrates to modi-fy their function, activity, solubility and ...
Dissecting the crosstalk between inhibitory receptor signaling and the T cell receptor in natural killer cells

Ergün, Ebru Zeynep. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2022., 2022)

Killer-cell immunoglobulin-like receptors (KIRs) are among the most prominent receptors regulating NK cell development and function. Most KIR ligands are the MHC class I molecules found on target cells. KIRs are responsible ...
Co-receptor mediated regulation of T cell receptor signalling in natural killer cells

Karahan, Zeynep Sena. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2022., 2022)

Antigen-specific cancer immunotherapy has been developing since the 1990s and showing promising results. T cell receptors (TCR) and Chimeric antigen receptors (CAR) are the most commonly used tools for modifying T cells ...
Further characterization of heart - and skeletal muscle-specific mitochondrial aspartyle -tRNA synthetase (DARS2) knockout mouse

Kartal, Özlem. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2022., 2022)

Mitochondrial respiratory chain defects are the primary cause of mitochondrial disorders. Mitochondria have developed various adaptive responses to counteract the effects of these defects. In this study, the heart- and ...
The role of MAPK and AKT signaling during zebrafish olfactory epithelium regeneration

Dokuzluoğlu, Zeynep. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2022., 2022)

The zebrafish olfactory epithelium (OE) is a neuroepithelium that is able to re generate neurons. The ability of the OE for neuron regeneration stems from the pres ence of a dual progenitor system that persists to the ...
Identification of HB-EGF positive and HB-EGF responsive cell populations in zebrafish olfactory epithelium

Güler, Kardelen. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2022., 2022)

The peripheral olfactory epithelium (OE) is an exception to the limited capacity of the adult nervous system to undergo neurogenesis, which supports structural repair in response to traumatic injury. It continuously and ...
Investigation of NLRP13's cleavage and its role in macrophage polarization

Çıracı, Sevgi. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2022., 2022)

The NOD-like receptors (NLRs) are mainly known for their roles in inflamma tory responses and host defense against microbial pathogens, but they are also asso ciated with metabolic disorders, autophagy regulation, transcription ...
Characterization of CkIIα-i1 -a putative ortholog of intellectual disability candidate gene ZBTB11

Mandacı, Barış Can. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2022., 2022)

Intellectual Disability (ID) is a heterogenic neurodevelopmental disorder seen in different spectrums in affected individuals. Resulting problems in the diagnosis of ID and limitations in its treatment constitutes a great ...
Identification of allosteric binding sites of the allatostatin receptor type-C of pine processionary moth

Kahveci, Kübra. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2022., 2022)

G-protein coupled receptors (GPCRs) are cell surface receptors that are consisted of seven-transmembrane α helices. Drugs targeting GPCRs account for one-third of clinically approved drugs; since many drugs target the ...
Investigation of the effects of ochratoxin-a on global protein sumoylation

Denizli, İrem. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2022., 2022)

Ochratoxin A (OTA), a secondary metabolite produced by especially Aspergillus and Penicillium species, is found as a contaminant in foods such as daily consumed corn flakes, coffee, meat and dairy products. OTA is a potential ...
The role of EGFR and JAK

Alkiraz, Aysu Şevval. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2022., 2022)

The zebrafish olfactory epithelium (OE) has an exceptional neurogenic capacity, which supports the continuous turnover olfactory sensory neurons (OSNs) and efficient regeneration after injury. These processes depend on the ...
Characterization of the E3 ubiquitin ligase RNFT2 ortholog CG13605 in drosophila melanogaster

Kahraman, Ayşe. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2022., 2022)

Characterized by deficits in both intellectual ability and adaptive behavior, intellectual disabilities (IDs) are one of the major neurodevelopmental disorders with a prevalence of 1- 3% worldwide. Development of Next ...
Investigation of the impact of human immunodeficiency virus on cellular sumoylation

Pekbilir, Emre. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2022., 2022)

The manifestation of Human Immunodeficiency Virus type 1 (HIV-1) infection is acquired immunodeficiency syndrome (AIDS), one of the major health problems worldwide. From the first step of infection to the end, HIV-1 ...
Preliminary characterization of a novel mitochondrial myopathy mouse model

Yılmaz, Mehmet. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2022., 2022)

Mitochondria provide a significant portion of the ATP to cells and govern cellu lar energy economics on ever-changing cellular energy requirements. Cells evolved to monitor mitochondrial stress and developed counteracting ...

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