Fen Bilimleri Enstitüsü: Recent submissions

  • Identification of interferon regulatory factor 4 (IRF4) - interacting proteins in melanoma cell lines 
    Erkan, Ekin Ece. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2015., 2015.)
    IRF4 is a member of interferon regulatory factor family of transcription factors. Previously, IRF4 was shown to have regulatory roles in immune cells and B-cell malignancies. In addition, IRF4 was recently shown to be ...
  • Expression analysis and behavioral assays in drosophila CMT models 
    Küey, Cansu. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2015., 2015.)
    Charcot–Marie–Tooth (CMT) disease is the most common inherited disorder of the peripheral nervous system. It is characterized by progressive distal sensory loss and weakness, muscle atrophy in hands and lower legs, and ...
  • Functional and morphological evaluation of drosophila CMT models 
    Gökerküçük, Elif Begüm. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2015., 2015.)
    Charcot-Marie-Tooth (CMT) disease is the most frequent inherited peripheral neuropathy in humans with a prevalence of 1 in 2500. It comprises a large group of genetically heterogeneous hereditary motor and sensory neuropathies ...
  • Bioinformatic and molecular analysis of olfactory receptor gene regulation in zebrafish 
    Kaya, Ahmet Burak. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2015., 2015.)
    In vertebrates, an individual olfactory sensory neuron (OSN) expresses only one allele of one olfactory receptor (OR) gene from a huge genomic repertoire. The molecular mechanism governing “one neuron-one receptor rule” ...
  • Does blocking of firoblast growth factor-1 and its receptors affect mouse peripheral nerve myelination? 
    Şimşek, Büşra. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2015., 2015.)
    Bi-directional communication between axon and Schwann cell is vital to the peripheral nervous system (PNS) myelination process. Disruption of this highly regulated communication is the main underlying reason of peripheral ...
  • In vivo characterization of the OR101-1 gene proximal promoter region in zebrafish 
    Kazcı, Yusuf E.. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2015., 2015.)
    In vertebrates, each olfactory sensory neuron (OSN) of the nose expresses only a single allele of a single molecular chemoreceptor gene from a large genomic repertoire. This monogenic mode of olfactory receptor (OR) ...
  • Regulation of olfactory receptor gene choice by negative regulatory elements 
    Sancer, Gizem. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2015., 2015.)
    In the olfactory system, each olfactory sensory neuron (OSN) typically expresses only one allele of a single olfactory receptor (OR) gene from a vast genomic repertoire. The mechanisms of OR gene choice, however, are not ...
  • Identification of pathogenic mutations in neurodegenerative disorders: bioinformatic analysis of next generation sequencing data 
    Kartal, Ece. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2015., 2015.)
    Neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis and ataxias belong to a large group of disorders, characterized by progressive neuronal cell death in specific ...
  • Identification of the upstream regulators of interferon regulatory factor 4 (IRF4) expression in melanoma cells 
    Tufan, Ahmet Buğra. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2015., 2015.)
    Melanoma is derived from melanin pigment producing cells which are known as melanocytes. Late stage, metastatic melanoma is considered as one of the most aggressive malignancies with one of the worst prognosis. IRF4 belongs ...
  • The possible involvement of SIK2 in diabetic retinopathy 
    Ersoy, Burcu. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2015., 2015.)
    Diabetic Retinopathy (DR) is one of the most common complications of diabetes and in advanced stages it is characterized by vascular abnormalities and neuronal degeneration. It is widely accepted that the functional changes ...
  • Functional characterization of a novel hexosaminidase, CG7985, in DROSOPHILA eye development 
    Kıral, Ferdi Rıdvan. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2015., 2015.)
    CG7985 is one of the four hexosaminidases encoded by the Drosophila genome. Although the other three hexosaminidases have been well-characterized in terms of their enzymatic activities and metabolic pathways in which they ...
  • Gene localization studies in two neurological disorders 
    Duru, Nadire. (Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2006., 2006.)
    Autozygosity mapping is a frequently used powerful method for discovering loci for autosomal recessive diseases resulting from consanguineous marriages. Gene localization is an initial step for the identification of genes ...
  • Characterization of NLRP13 in inflammasome activity 
    Yalçınkaya, Mustafa. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2015., 2015.)
    NOD-like receptors (NLRs) are a family of cytoplasmic proteins with members regulating inflammation and apoptosis. NLRP13 is a novel PYRIN domain containing NLR family member and the roles of NLRP13 in these pathways is ...
  • Olfactory neurogenesis following acute injury 
    Çapar, Serdar. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2015., 2015.)
    For most of the last century, it was believed that neurogenesis is limited to embryonic development and does not occur in the adult nervous system. However, it is now an established fact that neurogenesis also occurs in ...
  • The role of sustentacular cells in adult neurogenesis 
    Bali, Burak. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2015., 2015.)
    The olfactory epithelium (OE) provides a unique exception to the limited ability of the nervous system to regenerate itself. Olfactory sensory neurons (OSN) are directly exposed to the outside world, prone to environmental ...
  • Functional study of common bean isoliquiritigenin 2'-0- methyltransferase gene under salt stress 
    Niron, Harun. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2015., 2015.)
    Soil salinity has been one of the major problems in agriculture for many years. Nearly 20% of all cultivated land and half of irrigated land of world soil are saline and these levels are expected to rise in the future which ...
  • Selective neurogenesis in the zebrafish olfactory epithelium 
    Çoban, Büşra. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2015., 2015.)
    Neurogenesis in the adult nervous system is a limited process in higher vertebrates. The olfactory epithelium (OE) is an exception to this limitation and maintains the ability to regenerate lost neurons throughout the ...
  • Spinocerebellar Ataxia TYPE 2: Ataxin-2 mechanisms and boold biomarkers 
    Şen, Nesli Ece. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2015., 2015.)
    Spinocerebellar Ataxia Type 2 is an autosomal dominant movement disorder caused by trinucleotide expansions in the ATXN2 gene (>34 CAG repeats). Intermediate expansions of 26-39 repeats are considered as risk factors for ...
  • Genome-wide localisation analysis for IRF4 target gene identification in melanoma cell lines 
    Afshar, Ulduz Sobhi. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2015., 2015.)
    Interferon Regulatory Factor 4 (IRF4) is a key transcription factor in development and function of immune cells. Also it has been shown that elevated IRF4 expression is a key factor for survival in some myeloid and lymphoid ...
  • Identification of prominent genes and pathways in epilepsy patients by analysis of whole exome sequencing data 
    Erdoğan, Volkan. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2015., 2015.)
    Genome sequencing technologies are advancing at a very fast rate. Output of those technologies is large amounts of data that is inconvenient for manual analysis. There are statistical and machine learning methods to make ...

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