Moleküler Biyoloji ve Genetik: Recent submissions

  • Locus and gene search in three disorders 
    Hazan, Renin. (Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2009., 2009.)
    Identification of genetic defects associated with hereditary diseases is important in understanding cellular mechanisms and molecular etiology of diseases, developing diagnostic tests and novel therapeutic techniques. In ...
  • Class restriction in odorant receptor gene regulation 
    Tınaztepe, Emir. (Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2009., 2009.)
    Odorant receptors which partake in the detection of both water-soluble and airborne chemicals constitute the largest family of seven-transmembrane G-Protein-Coupled Receptors in the majority of vertebrates. Since their ...
  • Establishment of primary human skin cell culture and soft agar transformation assay 
    Sümer, Burcu. (Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2009., 2009.)
    The skin, the largest organ of the human body, is a complete closed system with various functions, including physical protection from the exterior hostile environment, sensing outside signals via its complex sensory system ...
  • A study for the detection of known and novel mutations in the cystic fibrosis transmembrane conductance regulator gene 
    Kılınç, Okyay. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 1996., 1996.)
    Cystic fibrosis (CF) is one of the most common and severe autosomal recessive genetic disorders worldwide. It results from mutations in the gene encoding the cystic fibrosis transmembrane conductance regulator (CFTR). ...
  • Characterization of C170RF45 as a novel target of the Wnt/β-catenin pathway 
    Şeker, Tuncay. (Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2009., 2009.)
    β-catenin is a key component of Wnt pathway which plays an important role in tumorigenesis. In our previous study, candidate genes regulated byWnt/ β-catenin/TCF pathway were identified in hepatocellular carcinoma-derived ...
  • Temporal and comparative analysis of genes that play a role in brain vascular development 
    Özkan, Abdulkadir. (Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2009., 2009.)
    Arteriovenous malformations (AVMs) are direct abnormal connections of arteries and draining veins without a capillary bed. AVMs, in which normal blood flow is interrupted, carry high risk of bleeding throughout life. They ...
  • Myotonic dystrophy: application of a novel triplet-repeat-primed-pcr approach to Turkish DM patients and molecular analysis of a large Turkish kindred with Von Hippel-Lindau disease 
    Eruslu, Didem. (Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2009., 2009.)
    Myotonic Dystrophy (DM) is an autosomal dominant neuromuscular disease with multisystemic effects. DM1 and DM2 are two clinically similar types of DM that are caused by different mutations on different genes. DM1, the more ...
  • Molecular genetic analysis of benign epilepsy syndromes 
    Kayserili, Melek Aslı. (Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2009., 2009.)
    Generalized Epilepsy with Febrile Seizures Plus (GEFS+) and Benign Familial Infantile Seizures (BFIS) are some of the benign epilepsy syndromes. GEFS+ is a collection of phenotypes that show febrile seizures beyond the age ...
  • Identification of novel proteins that interact with BR13, a putative transcriptional target of the Wnt/β-catenin signaling pathway 
    Akiva, İzzet. (Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2009., 2009.)
    The Wnt/β-catenin signaling pathway is an evolutionary conserved pathway which has important functions in vertebrate early development, axis formation, cellular proliferation and morphogenesis. The activation of this pathway ...
  • Verification of putative novel Wnt/ β-catenin pathway targets using alternative effectors 
    Aslan, Tolga. (Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2009., 2009.)
    The Wnt/β-catenin pathway plays important roles in embryogenesis, development and tissue homeostasis in adult organisms. Mutations in almost any member of this pathway have been associated with a disease including Alzheimer’s ...
  • Screening of spastin, atlastin, nipa1 and reep1 genes in hereditary spastic paraplegia patients 
    Atay, Çiğdem. (Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2008., 2008.)
    Hereditary Spastic Paraplegia (HSP), also known as Strümpell-Lorrain Syndrome or Familial Spastic Paraplegia (FSP), is a group of inherited neurodegenerative disorders that is characterized by progressive spasticity and ...
  • X-linked Charcot-Marie -Tooth neuropathy: mutation and haplotype analyses 
    Akat, İrem. (Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2009., 2009.)
    Charcot-Marie-Tooth disease is the most common peripheral neuropathy with a prevalence of 17-40 per 100.000 individuals. X-linked Charcot-Marie-Tooth (CMTX) disease accounts for up to 15% of all CMT cases. There are five ...
  • MENA, BR13 and HSF2 as novel transcriptional targets of the Wnt/β-catenin pathway 
    Najafov, Ayaz. (Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2008., 2008.)
    Wnt/β-catenin signaling pathway plays important roles in embryonic development and carcinogenesis, which makes the pathway and its targets important subjects in developmental biology and cancer research fields. In its ...
  • Mutational analysis of Factor XI and Von Willebrand Factor genes by high resolution melting analysis and direct DNA sequencing 
    Usluer, Sunay. (Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2008., 2008.)
    Continuous flow of blood is essential for life and its maintenance is an important task for the body. Hemostasis is the balance between the coagulants, factors that promote blood clot formation and anti-coagulants, factors ...
  • Genetic analysis in three inherited disorders 
    Bozoğlu, Tarık. (Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2008., 2008.)
    Genes responsible for inherited disorders can be localized on the genome by genetic linkage analysis. Mapping of a disease locus is accomplished by genotyping the family members with polymorphic markers in order to identify ...
  • Molecular genetic analysis of Lafora Disease and Dravet's Syndrome 
    Salar, Seda. (Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2008., 2008.)
    Lafora Disease (LD), a type of Progressive Myoclonus Epilepsy (PME) and Dravet’s Syndrome (DS), the most severe form in Generalized Epilepsy with Febrile Seizure Plus (GEFS+) spectrum, are debilitating examples of epilepsy ...
  • Importance of ASC expression levels in the development of chemoresistance in human melanoma cell lines 
    Erdoğan, Damla. (Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2008., 2008.)
    ASC (Apoptosis-associated speck like protein containing a CARD) is an adapter protein containing PYRIN and CARD interaction domains. ASC is implicated in apoptosis and innate immune signaling and is required for IL-1 and ...
  • Analysis of Turkish cystic fibrosis chromosomes 
    Akarsubaşı, Alper Tunga. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 1995., 1995.)
    Cystic fibrosis (CF results from mutations in the gene encoding the cystic fibrosis transmembrane regulator (CFTR), a protein that regulates chloride ion transport in exocrine gladns. Since the cloning of the gene, more ...
  • Expression of fibroblast growth factors and their receptors in developing mouse dorsal root ganglia 
    Erkut, Cihan. (Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2008., 2008.)
    Myelin is a key component of the nervous system where it discontinuously insulates axons and increases the speed of action potential propagation. The absence or insufficiency of myelin sheathing causes hereditary neuropathies. ...
  • Expression of SIK1 and SIK3 in postnatal rat retina 
    Vural, Muhammet Emin. (Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2008., 2008.)
    Salt-inducible kinases (SIKs) have been shown to be expressed in various cells and organs including adrenocortical tissue, adipocytes and liver. They were implicated in adipocyte differentiation, steroidogenic gene expression ...

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