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Recent submissions

Moleküler Biyoloji ve Genetik: Recent submissions

Now showing items 161-180 of 221

Development & application of novel methods to identify locus-specific transcriptional regulators

Selcen, İpek. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2019., 2019.)

Chromatin-associated factors play important roles in the regulation of gene expression. It is essential to identify these factors in order to elucidate their functional roles at the target sites. There are a number of ...
Investigation of the possible oncogenic role of NLRP7 in human endometrium canser

Olay Artık, Gizem. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2019., 2019.)

NLRP7 is an innate immune protein that is involved in the activation of proin ammatory caspases by participating in in ammasome oligomerization. So far, mutations in NLRP7 have been associated with Hydatidiform Mole ...
Mutational analysis of the ARX gene and whole exome sequencing in epileptic encephalopathy patients

Özünlü, Hande. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2019., 2019.)

The term epileptic encephalopathy (EE) is used to describe epileptic syndromes with generally early onset, within the first year of life, refractory to drug treatment and poor developmental outcome. The genetics of epileptic ...
Investigation of the pathogenic basıs of NEK1-linked amyotrophic lateral sclerosis and discovery of a potential treatment that prevents protein aggregation through targeted destruction

Öztürk, Harun. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2019., 2019.)

Amyotrophic lateral sclerosis (ALS) is a debilitating neurodegenerative disease with dismal prognosis, characterized by motor neuron loss in the patients. More than 30 genes have been reported to be involved in ALS ...
Identification of the major sumoylation site on crispr CAS9 protein

Yeşildağ, Duygu. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2019., 2019.)

CRISPR/Cas9 system is a type of adaptive immune system, which operates in prokaryotic organisms as an antiviral defense. Ever since its adaptation to eukaryotic systems as a gene editing tool, CRISPR has been one of the ...
Analysis of the vascular endothelial growth factor and angiogenin genes as risk factors for amyotrophic lateral sclerosis in the Turkish population; identification of a possible novel mutation

Güzel, Refika Mine. (Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2006., 2006.)

Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disorder, which is primarily characterized by the death of motor neurons in the cerebral cortex, spinal cord, and brainstem. Degeneration of motor neurons ...
Generation of CRISPR/Cas-mediated mutants of IROC genes and protein tagging for endogenous expression analysis in drosophila

Çayıroğlu, Ecem. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2019., 2019.)

In the olfactory system, correct olfactory receptor neuron (ORN) development depends on proper olfactory receptor (OR) gene expression and proper projection of axons to higher brain centers. Thus, during development, ORNs ...
A novel post-translational modification on the central CRISPR enzyme :|discovery of Cas9 ubiquitylation

Çelen, Arda Baran. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2019., 2019.)

The CRISPR/Cas9 system offers a simple method for genome engineering by utilizing the ability of the bacterial Cas9 enzyme to cleave any desired genomic region under the guidance of a complementary RNA molecule. Due to its ...
The role of WNT signaling during regenerative neurogenesis in the zebrafish olfactory epithelium

Eski, Sema Elif. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2019., 2019.)

The peripheral olfactory epithelium (OE) is a potentially insightful exception to the limited capacity of neurogenesis in the adult nervous system. The OE undergoes continuous generation of olfactory sensory neurons (OSNs) ...
In vitro and in vivo characterization of dmHexDC function

Erkol, Emir. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2018., 2019.)

Glycosylation of molecules is crucial for a wide variety of cellular processes ranging from cell-cell communication to cell differentiation and is altered in many neurodevelopmental disorders. β-hexosaminidases process ...
Involvement of Gab1 in Müller cell proliferation

Dilvin Yıldırım, Hanife. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2019., 2019.)

Müller cells, the major type of glial cells in the retina, are reactivated in response to most retinal injuries and diseases. In fish the reactivated Müller cells proliferate and transdifferentiate to make up for the lost ...
Investigation of in vitro and in vivo effects of ochratoxin a on autophagy and ubiquitin - proteasome system

Akpınar, Hafıze Ayşin. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2018., 2018.)

Ochratoxin A (OTA) is a mycotoxin produced by Aspergillus and Penicillium genera of fungi and contaminates food and feed. OTA deregulates various signaling pathways and provokes oxidative stress along with augmentation of ...
Investigating the role of G protein coupled receptor (GPCR) activation in ochratoxin a (OTA)- induced toxicity

Aylan, Beren. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2018., 2018.)

Ochratoxin A is recognized as a strong nephrotoxin accumulating and initiating cellular damage in kidney proximal tubule cells. OTA exerts its eﬀects both on cell sur vival and cell death via the deregulation of mitogen ...
Characterization of adipokinetic hormone receptor in stick insect, Carausius Morosus

Sınmaz, Merve Gizem. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2018., 2018.)

Adipokinetic hormone (AKH) is an insect neuropeptide and known as gonadotropinreleasing hormone, which is orthologue to humans. It is released from corpora cardiaca and acts generally on fat body for energy mobilization. ...
Investigation of NLRP13 - driven innate immune responses

Yılmazer, Açelya. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2018., 2018.)

NOD-like receptors are the key players of inﬂammasome activation. NLRP13 is a primate speciﬁc member of the NLR family containing PYRIN domain and its role in inﬂammation is still unknown. Since there is no published ...
Investigation of the effects of NF-kB on ota induced apoptosis in HK-2 cell line

Gürkaşlar, Can. (Thesis (M.A.) - Bogazici University. Institute for Graduate Studies in the Social Sciences, 2018., 2018.)

Ocharoxin A (OTA) is a mycotoxin produced by certain species of Aspergillus and Peni cillium genera of fungi. OTA was shown to be carcinogenic, genotoxic, immunotoxic by many studies and main suspected causative agent for ...
Molecular analysis of hemoglobinopathies and construction of a database; identification of a novel IVS-II-2 (T-A) mutation

Latif, Ayşe. (Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2006., 2006.)

Hemoglobinopathies, inherited disorders of the hemoglobin (Hb) molecule, display great molecular and phenotypic diversity. Beta-thalassemia major is considered as the most severe form of hemoglobinopathies and requires ...
Transcriptome - wide analysis of iroc target genes in the drosophila olfactory system

Taşkıran, İbrahim İhsan. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2018., 2018.)

Sensing the environment is vital for an organism and it is provided by divergent sensory neurons. These neurons are generated from sensory organ precursor (SOP) cells that differentiate into neurons with diverse spectral ...
Clonal analysis of compensatory proliferation in dmHexDC mutants

Başdağ, Bilal. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2018., 2018.)

Recycling of sugar-containing organic compounds (saccharides) have importance for metabolic activity, cellular growth, and differentiation. During this recycling process, many enzymes, primarily lysosomal enzymes, play a ...
Is FGF1 acting as a promoter of remyelination in peripheral nervous system?

Özkan, Nazmiye. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2018., 2018.)

Bidirectional and continuous communication between Schwann cells (SCs) and axons are crucial for peripheral nervous system (PNS) myelin development, maintenance, and repair after injury. Disruption of SCs-axon interaction ...

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