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Ph.D. Theses: Recent submissions

Now showing items 21-40 of 51

Synthesis, evlatuation of functional methacrylates and a computational approach to the reactions of molecules with biological potential

Agopcan, Sesil. (Thesis (Ph.D.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2017., 2017.)

In this dissertation, experimental and computational methods are used to in vestigate the molecules which are biologically active and have potential in pharma ceutical ﬁeld. This study sheds light on the synthesis procedures ...
Assessing protein - ligand binding modes, novel drug skeleton candidates for PDE4B and conformational rearrangements of EF-TU in GTP hydrolysis with computational tools

Çifci, Gülşah. (Thesis (Ph.D.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2017., 2017.)

In the first part of this dissertation, computer-aided drug design approaches, structurebased methodologies such as docking, molecular dynamics simulations and Gibbs free energy calculations with Molecular Mechanics-Generalized ...
Active and passive tumor targeting via micellar dendritic constructs

Sümer, Burcu. (Thesis (Ph.D.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2017., 2017.)

Among many other nanotherapeutics, polymeric micellar systems are emerging as a very important class of nano-pharmaceuticals due to their ability to improve pharmacokinetics and bio-distribution of chemotherapy drugs as ...
Reactive and 'clickable' hydrophilic nanofibers as novel biomaterials

Kalaoğlu Altan, Özlem İpek. (Thesis (Ph.D.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2017., 2017.)

Among many other nanomaterials, polymeric nanofibers have gained attraction in biomedical applications due to their unique properties such as high surface area, porosity and physical resemblance to the extracellular matrix. ...
Smart polymeric prodrugs for targeted drug delivery and functionalizable hydrogels for biosensing applications

Kağa, Sadık. (Thesis (Ph.D.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2016., 2016.)

Biosensing applications have an enormous place for diagnosis of numerous diseases. New platforms and materials have been developed to detect markers for several diseases. However, well defined materials are required for ...
Atroposelective synthesis and reactions of axially chiral thiohydantoins

Sarıgül, Sevgi. (Thesis (Ph.D.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2017., 2017.)

Nonracemic axially chiral thiohydantoins were synthesized atroposelectively by the reaction of ortho-arylisothiocyanates with amino acid ester salts in the presence of triethylamine (TEA). However, the synthesis of the ...
Modeling the solvent effect, kinetics, morphology and catalysis in polymerization reactions

Özaltın, Tuğba. (Thesis (Ph.D.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2016., 2016.)

In this dissertation, quantum chemical tools, in particular density functional theory (DFT), molecular dynamics (MD) and coarse-grained (CG) simulations are used to address the solvent e ect, kinetics, morphology and ...
Polymeric tubes prepared from poly (vinyl alcohol) fiber templates

Çavuşoğlu, Jesmi. (Thesis (Ph.D.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2016., 2016.)

In this study, the fabrication of covalently crosslinked polymeric tubes by using poly(vinyl alcohol) (PVA) fiber templates has been demonstrated. The crosslinking on the surface of PVA fiber templates was achieved by two ...
Molecular dynamics study of macromolecular motions and polypeptide helical stabilities in solution

Doruker, Pemra. (Thesis (Ph.D.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 1995., 1995.)

Molecular dynamics simulations have been performed to investigate the relative importance of solvent effect and intramolecular conformational potentials on the properties of polymers in dilute solition. Bead-spring, ...
Functional macromolecular platforms: hydrogel and soluble polymer-based materials for biomedical applications

Arslan, Mehmet. (Thesis (Ph.D.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2015., 2015.)

Design, fabrication and applications of novel hydrogel and soluble polymer-based macromolecular platforms employing functional polymer building blocks are described. Several click chemistry-based transformations and ...
Modeling the selectivity, catalytic and binding effects in organic reactions and protein environment

Dedeoğlu, Burcu. (Thesis (Ph.D.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2015., 2015.)

In this dissertation, quantum chemical tools, in particular density functional methods are used to address problems related with the selectivity, catalytic and binding effects in different fields of chemistry, such as ...
Investigation of the deamidation reaction in the enzyme triosephosphate isomerase by means of computational chemistry tools

Uğur, İlke. (Thesis (Ph.D.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2014., 2014.)

Deamidation is the posttranslational modi cation of asparagine (Asn) and glutamine (Gln) residues, which is observed in several proteins and peptides. It has been shown that deamidation limits the lifetime of these ...
Aromatic carboxamides as non-steroidal inhibitors of CYP17 for the treatment of prostate cancer

Köseoğlu, Ahmet. (Thesis (Ph.D.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2015., 2015.)

Cancer is the most common neoplasm of the prostate in developed countries. Since up to 80 % of Prostate Cancer (PCa) proliferation depends on androgens, most patients take hormone therapy as first choice of treatment. The ...
Linear and multi-arm functionalizable polymeric constructs for targeted drug delivery and imaging applications

Gök, Özgül. (Thesis (Ph.D.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2014., 2014.)

Multifunctional polymers with different architectures were designed as macromolecular carriers for drug delivery and imaging applications. To this end, linear and multiarm copolymers incorporated with reactive groups were ...
Synthesis of novel potent drug molecules active against prostate cancer and investigation of bioactive properties of cyclopolymers obtained by raft polymerization

Erkoç, Selda. (Thesis (Ph.D.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2011., 2011.)

The first part of the thesis includes synthesis of novel potent drug molecules active against prostate cancer. Structure-based drug design (SBDD) approach was used to discover novel lead compounds active against CYP17 by ...
Synthesis and evaluation of novel phosphonated and bisphosphonated methacrylates with possible environmental and biomedical applications

Bilgici, Zeynep Saraylı. (Thesis (Ph.D.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2013., 2013.)

In this study, a series of mostly alkyl α-hydroxymethacrylate (RHMA)-derived novel monomers in four groups, and polymers of some of them were synthesized for various purposes including dental, bone-targeting and metal-binding ...
Liposomes for encapsulating drugs and complexing DNA

Çağdaş, Fatma Melis. (Thesis (Ph.D.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2013., 2013.)

Surface-active substances, amphiphiles, show the ability of self-organization in solvents, forming self-assemblies with a large variety of morphologically different structures. One of these structures is liposomes, formed ...
Experimental and computational investigation of structure- reactivity relationship of methacrylates

Karahan, Özlem. (Thesis (Ph.D.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2012., 2012.)

In the first part of this work, a series of alkyl α-hydroxymethacrylates (RHMA) were synthesized and computationally modeled in order to understand the structure-reactivity relationships in their polymerizations. Several ...
Synthesis of axially chiral thiazolidine derivatives and their atroposelective reactions

Erol, Şule. (Thesis (Ph.D.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2012., 2012.)

In this study, various axially chiral thiazolidine-4-one and 4-thiones and their corresponding 5-benzylidene derivatives were synthesized in which the N3(sp2)-Carylbond rotation is hindered and used as scaffolds for the ...
Chain extension reactions of unsaturated polyesters using difunctional molecules

Taylan, Ediz. (Thesis (Ph.D.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2011., 2011.)

In this study the effectiveness of various chain extenders in increasing the molecular weight of unsaturated polyesters was investigated. For this purpose eight different chain extenders (with di or multi-functionalities) ...

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