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M.S. Theses: Recent submissions

Now showing items 101-120 of 178

Characterization of gene expression alterations in β-catenin activated Huh7 hepatocarcinoma cell lines by construction and verification of a sage library

Çavuşoğlu, Kader. (Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2007., 2007.)

β-catenin, a cytoplasmic component of the Wnt signaling pathway, is observed to be aberrantly activated in several types of tumors, including hepatocellular carcinoma. The aim of this study is to identify novel genes that ...
Analysis of the Cx32, MPZ and PMP22 mutations in the Turkish Charcot-Marie-Tooth patients

Maracı, Nazmiye Öncü. (Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2006., 2006.)

Charcot-Marie-Tooth disease is the most common hereditary peripheral neuropathy with a prevalence rate of one in 2500. Although the disease is classified as demyelinating and axonal CMT based on clinical investigations, ...
SIK2 is potential mediator of cross-talk between FGF and PKA pathways

Candaş, Demet. (Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2007., 2007.)

FGF signaling pathway is initiated upon FGF binding to RTKs and the signal transduction is achieved by a series of phosphorylation/dephosphorylation events mediated by several kinase and phosphatases. The pathway is tightly ...
Identification of candidate substrates of SIK2 in vitro

Küser, Gamze. (Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2006., 2006.)

SIK2 is a serine/threonine kinase widely expressed in rat retina and it is postulated to be a potential regulator of FGF signal transduction in retina. The aim of this work is to explore a link between SIK2 and FGF/ERK ...
Cloning, expression and purification of recombinant elongation factor Tu from hyperthermophilic bacteria Geobacillus Anatolicus

Akalın, Barış. (Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2006., 2006.)

In this study, elongation factor Tu (EF-Tu) from Geobacillus anatolicus was cloned, expressed and purifed as a His-tagged recombinant protein in Escherichia coli. At first, the nucleic acid sequence of Geobacillus anatolicus ...
Molecular analysis of Alzheimer's disease and frontotemporal dementia: anovel mutation in the presenilin 1 gene of a Turkish patient with early onset familial Alzheimer's disease

Hocaoğlu, Fatma Sinem. (Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2006., 2006.)

Alzheimer’s Disease (AD) and Frontotemporal Dementia (FTD) are the most common causes of dementia and death in developed countries. AD is clinically characterized by a progressive decline in cognitive functions. In most ...
Cardiovascular disease in the Turkish population: molecular analysis of the renin-angiotensin system and its associated genes with premature myocardial infarction

Gencer, Pınar. (Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2006., 2006.)

Cardiovascular disease (CVD), which is a complex multifactorial disease with many environmental and genetic factors, is the leading cause of death worldwide. Extensive research is ongoing for the identification of the ...
A molecular investigation of β-thalassemia in the Aegean and Mediterranean coasts of Turkey :|is there a region-dependent specificity?

Senga, Edward Bisweck. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 1994., 1994.)

As in many other Mediterranean countries, β-Thalassemia is also a major public health concern in Turkey. The average gene frequency.is estimated to be two per cent, and regions with higher figures are known to exist. Country ...
Identification of the gene responsible for pulmonary alveolar microlithiasis and possibly associated with testicular microlithiasis

Corut, Ayşe. (Thesis (M.S.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2006., 2006.)

In this study two inherited disorders, namely pulmonary alveolar microlithiasis (PAM) and testicular microlithiasis (TM), were studied. PAM is a rare autosomal disease characterized by the deposition of calcium phosphate ...
Genetics of hereditary sensory and autonomic neuropathy (HSAN)

Tezel, Seden. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2020., 2020.)

Hereditary Sensory Neuropathy (HSN), predominantly affects sensory nerves and is characterized by sensory loss in addition to muscle weakness, wasting and painless injuries. Autonomic symptoms are commonly associated with ...
Investigation of IRF4-MEF2D protein-protein interaction in melanoma cells

Hedaya, Laila Samir Abed. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2021., 2021.)

Cancer is a leading cause of death worldwide. Protein-protein interactions (PPIs) constitute a fundamental unit of the oncogenic signaling pathways that stimulate survival, growth and proliferation of cancer cells. Therefore, ...
Investigation of homotypic PYD and CARD domain interactions in ASC speck assembly

Otaş, Hasan Ozan. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2019., 2019.)

Apoptosis-associated speck-like protein containing a CARD (ASC) is a 22 kDa protein containing conserved PYD and CARD domains that belong to death-fold superfamily. Homotypic interactions between the domains occur via ...
A novel tool for the identification of locus-specific chromatin proteins

Ogmen, Anna. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2019., 2019.)

Genomic DNA is maintained and regulated by chromatin proteins. Methods for research of chromatin organization are numerous and established, however, it is still a challenge to identify novel chromatin proteins associated ...
Verification of novel Wnt/beta-catenin pathway targets

Kayabaşı, Ayşe Nur. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2019., 2019.)

One of the most fundamental signal transduction cascades, the Wnt/β-catenin signaling pathway, is an evolutionary conserved pathway in vertebrates which controls embryonic development and adult homeostasis. Signaling through ...
The assessment of ubiquitin E3 ligase activity of RNF4 on ALS-related NEK1 protein

Canaslan, Sezgi (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2019., 2019.)

Amyotropic lateral sclerosis (ALS) is a serious and progressive motor-neuron disease in which neurons that control voluntary muscles gradually deteriorate. Patients lose the ability to speak, move and breathe. To date, 30 ...
Investigation of the role of IroC in asymmetric cell division

Kanacı, Duran Emre. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2019., 2019.)

Drosophila melanogaster olfactory system has a high range of neural diversity. During pupal development, Olfactory Receptor Neurons (ORNs) are diversified within the sensory organ lineage emerges from a Sensory Organ ...
Development of a new vaccine technology using the carrier/adjuvant properties of ASC specks

Alkan, Aylin. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2019., 2019.)

Pathogen-associated molecular patterns (PAMPs) and danger-associated molecular patterns (DAMPs) are sensed by the nucleotide-binding oligomerization domainlike receptor (NLR) family of proteins in the cytosol for the ...
Development & application of novel methods to identify locus-specific transcriptional regulators

Selcen, İpek. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2019., 2019.)

Chromatin-associated factors play important roles in the regulation of gene expression. It is essential to identify these factors in order to elucidate their functional roles at the target sites. There are a number of ...
Investigation of the possible oncogenic role of NLRP7 in human endometrium canser

Olay Artık, Gizem. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2019., 2019.)

NLRP7 is an innate immune protein that is involved in the activation of proin ammatory caspases by participating in in ammasome oligomerization. So far, mutations in NLRP7 have been associated with Hydatidiform Mole ...
Mutational analysis of the ARX gene and whole exome sequencing in epileptic encephalopathy patients

Özünlü, Hande. (Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2019., 2019.)

The term epileptic encephalopathy (EE) is used to describe epileptic syndromes with generally early onset, within the first year of life, refractory to drug treatment and poor developmental outcome. The genetics of epileptic ...

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