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Recent submissions

Ph.D. Theses: Recent submissions

Toplam kayıt 42, listelenen: 21-40

Characterization of novel Wnt/β-catenin pathway targets

Akiva, İzzet. (Thesis (Ph.D.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2016., 2016.)

The Wnt/β-catenin signaling pathway is an evolutionary conserved pathway which has important functions in vertebrate early development such as axis formation, cellular proliferation and morphogenesis. The activation of ...
Negative regulation of Müller reprogramming by SIK2

Uğurlu, Aslı. (Thesis (Ph.D.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2016., 2016.)

In fish it is well known that Müller cells proliferate, gain stem cell characteristics and generate new neurons upon injury. Proliferation is as essential step in retina regeneration and in mammals its tight regulation in ...
Neurogenesis and migration of specified chemosensory neurons in the adult zebrafish olfactory epithelium

Bayramlı, Khalid. (Thesis (Ph.D.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2016., 2016.)

In the framework of this study, a systematic and quantitative analysis of the neurogenic process and the integration of adult-born olfactory sensory neurons (OSNs) into the zebrafish olfactory epithelium (OE) was performed. ...
Molecular and cellular development of cortical projection neurons: specification, diversity, and directed differentiation from endogenous progenitors for functional circuit repair

Özkan, Abdulkadir. (Thesis (Ph.D.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2016., 2016.)

Responsible for perception, integration of sensory information, cognitive function, motor control, and consciousness, the complex, yet highly organized, six-layered mammalian neocortex contains distinct classes of neurons. ...
Parkinson's disease in a large Turkish pedigree with SNCA duplication (PARK4): complexin-1 as a potent biomarker for predictive diagnosis

Lahut, Suna. (Thesis (Ph.D.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2015., 2015.)

Accumulation and aggregation of alpha-synuclein (SNCA) is a hallmark of Parkinson’s disease (PD). Considering the roles of SNCA in both idiopathic and familial PD, we studied blood samples from a large pedigree with SNCA ...
Transcriptome analysis of common bean under salt stress and functional study of salt responsive genes

Hız, Mahmut Can. (Thesis (Ph.D.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2015., 2015.)

Salinity is a major abiotic stress that impairs physiology and productivity of economically important crops such as common bean. It is an important grain legume and provides 30% of the protein diet in developing countries. ...
Identification of novel genes involved in the etiology of benign neonatal / infantile epilepsy syndromes and genetic epilepsy with febrile seizures plus (GEFS+)

Usluer, Sunay. (Thesis (Ph.D.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2015., 2015.)

Epilepsy is among the most prevalent episodic neurological disorders. Genetic factors play a major role in the etiology of epilepsy. This thesis included analysis of families with distinct epilepsy phenotypes in order to ...
SIK2 functions as a novel tumor suppressor in the breast tumorigenesis

Zohrap, Neslihan. (Thesis (Ph.D.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2015., 2015.)

Breast cancer has highly malignant phenotype and is the leading cause of cancer death in women. The heterogenous character of the disease points to the importance of novel target identification for the development of ...
Elucidating the role of unzipped in the visual system of drosophila

Terzioğlu Kara, Ece. (Thesis (Ph.D.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2015., 2015.)

The Drosophila eye is composed of 800 ommatidial units, each containing eight photoreceptors (PR). The outer PRs R1-R6 are responsible for motion detection, while the inner PRs R7 and R8 and are responsible for colour ...
The myelination puzzle: do fibroblast growth factors and their receptors have regulatory roles in peripheral nerve myelination?

Dağlıkoca, Emine Duygu. (Thesis (Ph.D.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2014., 2014.)

Axon-Schwann cell interaction is the key step in myelination and critical in the pathogenesis of peripheral neuropathies. Molecules mediating this interaction to promote the complex mechanism of myelination have not been ...
Beta thalassemia in Turkey: |distribution, diversity, evolution and phenotype-genotype correlations

Tadmouri, Ghazi Omar. (Thesis (Ph.D.)- Bogazici University. Institute for Graduate Studies in Science and Engineering, 1999., 1999.)

The present study illustrates the results of years of research on different aspects of beta-thalassemia in Turkey. Methods to detect the C-T change at position -158 upstream of the Gy-globin gene and the (AT)xTy motif 5' ...
SIK2: a key player in FGF2-induced proliferation and insulin-induced survivale/hyperglycemia-dependent apoptosis in müller cells

Küser, Gamze. (Thesis (Ph.D.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2011., 2011.)

Salt inducible kinase 2 (SIK2), a serine/threonine kinase, is primarily expressed in insulin-responsive tissues. It was suggested that SIK2 might be involved in type 2 diabetes by phosphorylating S789 residue of IRS1. In ...
Regulation of human BFK

Uğurlu, Serkan. (Thesis (Ph.D.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2014., 2014.)

Bcl-2 protein family members are critical regulators for apoptosis. Reduced levels of apoptotic Bcl-2 family members are detected in gastrointestinal cancers which are responsible for a considerable part of the deaths from ...
Development of single cell genetic testing strategies : assessment of MHC compatibility, meiotic recombinations and beta-thalassemia in human embryos

Taylan, Fulya. (Thesis (Ph.D.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2011., 2011.)

Single cell molecular biology, a relatively new scientific branch, is promising to study unique questions and leading to novel applications in biology and medicine. Single cell studies have been challenged by difficulties ...
Amyotrphic lateral sclerosis in Turkey : Studies on Familial and sporadic ALS using high-throughput genomic technologies

Özoğuz, Aslıhan. (Thesis (Ph.D.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2010., 2010.)

Amyotrophic Lateral Sclerosis (ALS) is a late-onset neurodegenerative disease, characterized by death of motor neurons in cortex, brainstem and spinal cord. It is a multifactorial disease with interacting pathogenic ...
Gene hunt in four inherited diseases

Çetinkaya, Murat. (Thesis (Ph.D.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2010., 2010.)

Genetic linkage analysis is applied to identify loci that harbor gene or genes associated with a disease. It is possible to map disease loci by observing alleles the segregation of microsatellite or SNP markers with the ...
Characterization of thermophilic gene expression enzymes

Çağlayan, Melike. (Thesis (Ph.D.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2010., 2010.)

The DNA polymerase I genes of seven newly identified Geobacillus species within the family Bacillaceae, were cloned, sequenced and overexpressed in Escherichia coli. The polA gene of these species encodes DNA polymerase I ...
Mutation profile of hemophilia a patients with inhibitors and association of interleukin and cytokine gene polymorphisms with inhibitor development

Fidancı, İnanç Değer. (Thesis (Ph.D.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2010., 2010.)

Hemophilia A (HA) is an X linked recessive bleeding disorder characterized by qualitative and quantitative deficiency in the factor VIII (FVIII) protein, mainly caused by Factor 8 (F8) gene mutations. A severe complication ...
Defining novel cancer genes, sage tags and co-regulated regions of the human genome evolving from the search and identification of novel Wnt/TCF/B-catenin targets

Kavak, Erşen. (Thesis (Ph.D.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2009., 2009.)

The Wnt signaling pathway is involved in many differentiation events during embryonic development and can lead to tumor formation after aberrant activation of its components. β-catenin, a cytoplasmic component, plays a ...
Absence epilepsy in Turkish patients: a novel gene at susceptibility locus 2q36 and the role of GABRG2

Çapan, Özlem Yalçın. (Thesis (Ph.D.)-Bogazici University. Institute for Graduate Studies in Science and Engineering, 2009., 2009.)

Idiopathic absence epilepsies (IAE) are complex disorders mainly caused by genetic factors. Two major whole-genome linkage studies performed on many IAE samples pointed to chromosome 2q36 as a susceptibility locus for ...

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