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dc.contributor Graduate Program in Chemistry.
dc.contributor.advisor Sanyal, Rana.
dc.contributor.author Özer, Enfal.
dc.date.accessioned 2023-03-16T11:00:57Z
dc.date.available 2023-03-16T11:00:57Z
dc.date.issued 2019.
dc.identifier.other CHEM 2019 O87
dc.identifier.uri http://digitalarchive.boun.edu.tr/handle/123456789/14397
dc.description.abstract Polymeric architectures are widely used in polymer therapeutics for both imaging and drug delivery applications. Design of these polymer drug conjugates consists of three parts: water soluble monomer, linker and the drug or imaging agent. Linkers are chosen according to the stimuli which is preferably overexpressed in the tumor environment. In addition to polymeric scaffolds, targeting agents can be introduced to these systems. As a targeted drug delivery agent, antibody drug conjugates have been used in the market recently for the treatment of cancer. Antibody ensures specific targeting of the cargo due to strong affinity to their receptors. However, these agents are limited by the number of drug molecules they can carry. To overcome this limitation, polymer is conjugated to antibody where the payload is carried by this polymer. As a model system, trastuzumab is conjugated to dye bearing polymers.
dc.format.extent 30 cm.
dc.publisher Thesis (M.S.) - Bogazici University. Institute for Graduate Studies in Science and Engineering, 2019.
dc.subject.lcsh Drug delivery systems.
dc.subject.lcsh Immunoglobulins.
dc.title Investigation of antibody-dye conjugates
dc.format.pages xiv, 45+4 leaves ;


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