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Working memory performance assessment while monitoring the prefrontal cortex hemodynamics by means of functional near infrared spectroscopy

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dc.contributor Graduate Program in Biomedical Engineering.
dc.contributor.advisor Akın, Ata.
dc.contributor.author Kırımlı, Ceyhun Ekrem.
dc.date.accessioned 2023-03-16T13:12:04Z
dc.date.available 2023-03-16T13:12:04Z
dc.date.issued 2008.
dc.identifier.other BM 2008 K57
dc.identifier.uri http://digitalarchive.boun.edu.tr/handle/123456789/18748
dc.description.abstract One of the popular experimental paradigms for functional neuroimaging studies of working memory (WM) has been the n-back task, in which subjects were asked to monitor the identity or location of a series of verbal or nonverbal stimuli and to indicate when the currently presented stimulus is the same as the one presented n trials previously. It is known that dorsoleateral and ventrolateral prefrontal cortex (PFC) is especially active during cognitive task requiring working memory performance. Functional near-infrared spectroscopy (fNIRS) is an optical imaging method, which allows non-invasive in vivo measurements of changes in the concentration of oxygenated (HbO2) and deoxygenated (DeoxyHb) haemoglobin in cortical tissue. In this thesis fNIRS was used to determine the activity on PFC of 9 graduate student subjects, who were asked to take an n-back test involving WM load. A gamma function variate was used to model the hemodynamic response behavior during the task and statistical analysis was applied to determine parameters from the near infrared spectroscopic signals that are in correlation with the WM load. A correlation between the working memory load and hemodynamic response function parameters determined form NIRS signal, was observed on left and right channels on the forehead probe. Model applied in this thesis enabled a quantification of the WM load solely by using fNIRS as a neuroimaging device.|Keywords: Functional Near-Infrared Spectroscopy, Working Memory, n-back, Prefrontal Cortex, Gamma function, Hemodynamic Response Function.
dc.format.extent 30cm.
dc.publisher Thesis (M.S.)-Bogazici University. Institute of Biomedical Engineering, 2008.
dc.relation Includes appendices.
dc.relation Includes appendices.
dc.subject.lcsh Near infrared spectroscopy.
dc.subject.lcsh Short-term memory.
dc.subject.lcsh Prefrontal cortex.
dc.subject.lcsh Gamma functions.
dc.title Working memory performance assessment while monitoring the prefrontal cortex hemodynamics by means of functional near infrared spectroscopy
dc.format.pages x, 49 leaves;


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